A monograph in Bannerstone division, American lectures in living chemistry.
|Series||American lecture series -- no. 790, American lectures in living chemistry|
Additional Physical Format: Online version: Porter, Curt C., Chemical mechanisms of drug action. Springfield, Ill., Thomas  (OCoLC) Chemistry and Molecular Aspects of Drug Design and Action - CRC Press Book An ever-increasing demand for better drugs, elevated safety standards, and economic considerations have all led to a dramatic paradigm shift in the way that drugs are being discovered and developed. There are several major targets of drug action: nucleic acids, specific metabolic and signaling enzymes, and microtubules. When nucleic acids are the target, it is generally an action on the integrity or synthesis of DNA rather than of RNA that is presumed to cause cell by: 3. Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book 3/5(4).
Actions of drugs are the biochemical physiological mechanisms by which the chemical produces a response in living organisms. The effect is the observable consequence of a drug action. For example, the action of penicillin is to interfere with cell wall synthesis in . Learning Objectives. • Develop an understanding of the scientific basis for drug development, drug mechanisms, drug disposition and drug safety • Develop an appreciation for the role of pharmacokinetics, drug metabolism and drug interactions in the mechanisms of drug action • Understand the balance between environment and pharmacogenetics in the toxicity and therapeutic outcome associated with a drug • Understand factors that lead to success and failure in drug File Size: KB. The Neuropharmacology of Drugs of Abuse 3 rugs of abuse interact with the neurochemical mecha- the chemical structure of a drug plays an impor- These drugs have various mechanisms of action, but their net effect is to stimulate central nervous system (CNS) activity. Mechanisms of Drug Action Volume 1. Editors (view affiliations) G. N. Woodruff; Book. 8 Citations; Chemical Transmission in the Central Nervous System: Amino Acids, Acetylcholine and Amines Mechanisms of Action of Neuromuscular Blocking Drugs. W. C. Bowman. Pages Ganglion Blockers. V. I. Skok. Pages Benzodiazepine.
This book represents a new approach based on physical organic chemical principles and reaction mechanisms that rationalize drug action and allow the reader to extrapolate to many related classes of drug . Introduction. Objectives. After completing this chapter, the reader should be able to. Describe the various mechanisms in which drug mol- ecules elicit their effects. Illustrate the effects of receptor-mediated agonists and antagonists. Describe the differences between competitive, non-. competitive, and allosteric antagonism. Compare and contrast the differences and similarities between ionophoric and File Size: 1MB. The mechanisms of action include inhibition of bacterial protein synthesis, inhibition of cell wall synthesis, inhibition of enzymatic activity, alteration of cell membrane permeability, and blockade of specific biochemical pathways. This is an updated, expanded new edition of Dr. Ruth Levine's renowned Pharmacology: Drug Actions and Reactions. It covers basic pharmacological principles and the general concepts of chemical-biological interactions and now includes important new material on molecular biology, updated clinical information, and added coverage of the newer drugs.4/5(3).